Ovarian granulosa cell tumor gct is a malignant tumor originating from the sexcord stromal cells of the ovary. In addition, 33 surface epithelial neoplasms, 12 germ cell tumors, 11 metastases, and 11 miscellaneous ovarian neoplastic proliferations were evaluated. Granulosa cell tumors gcts of the ovary account for 2 to 5 of ovarian malignancies. A composite mucinous and granulosa cell tumor of the ovary in a 76. Adult granulosa cell tumors appear more often than the juvenile type and occur usually in postmenopausal women. In addition to the tumor stage, residual disease, patient age, tumor size. Granulosa cell tumours are tumours that arise from granulosa cells. If you have problems viewing pdf files, download the latest version of adobe reader. Composite mucinous and granulosa cell tumor of the ovary.
There is also a private facebook group of almost 600 women diagnosed with gct called gct survivor sisters that you can request to join. Granulosa cell tumors of the ovary are rare neoplasms that originate. Juvenile granulosa cell tumor is an uncommon testicular tumor, most frequently seen in newborns and infants below the age of 2 years. May 16, 2012 ovarian granulosa cell tumor gct is a malignant tumor originating from the sexcord stromal cells of the ovary. Short report cisplatincontaining regimen in advanced or recurrent granulosa cell tumours of the ovary d. They account for most of the hormonally active ovarian tumors.
The objective of this study was to determine the clinicopathologic prognostic factors in adult granulosa cell tumors of the ovary. Patients may present with nonspecific symptoms such as abdominal pain, distention, or bloating. Gct exhibit a molecular profile that is consistent with fshresponsive granulosa cells of. These tumors are the principal feminizing neoplasms of the ovary. A new classification of ovarian granulosa cell tumor based on. Granulosa cell tumor of the ovary radiology reference. Sex cordstromal tumors of the ovary are rare ovarian neoplasms, which arise from stromal cells and primitive sex cords in the ovary. Characteristics and treatment results of recurrence in. The expression levels of foxl2 were similar across the adult granulosa cell tumors and the normal ovary controls. Granulosa cell tumor of the ovary genetic and rare diseases nih. Well for being such a rare form of ovc, there seems to be a lot of us here. The aim of this study was to report the clinical and pathological characteristics of agct patients and to identify the prognostic factors. The imaging system provides some classic features, which can assist to diagnose the granulosa cell tumor. A new classification of ovarian granulosa cell tumor based.
Epidemiology sex cordstromal tumors represent approximately 8% of all ovarian tumors and are believed to arise from andor to contain combinations of the sex co. Huntsmand,e and markku heikinheimob,f adepartment of obstetrics and gynecology, university of helsinki and helsinki university hospital, helsinki, finland. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a womans body. Granulosathecacell tumor of the ovary in children jama. In patients with a granulosa cell tumor of the ovary, the value of serum inhibin a and b concentrations for the assessment of disease status was investigated. Presentation of two patients with malignant granulosa cell. Granulosacell tumor of ovary with sexual precocity jama. Dec 01, 2012 well for being such a rare form of ovc, there seems to be a lot of us here. We are not able to provide medical advice or cancer specialist referrals. Discussion granulosa cell tumors of the ovary are uncommon tumors with an indolent course. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant gct.
Patients may present with vaginal bleeding caused by endometrial hyperplasia or uterine cancer as a result of prolonged exposure to tumor derived estrogen. For language access assistance, contact the ncats public information officer. Sex cordstromal and steroid cell tumors of the ovary. Clinical, pathologic, and followup data were collected. This seems to be a very rare type of ovarian cancer. The granulosa cell tumor of the ovary foundation gctf exists to raise funds for granulosa cell tumor of the ovary gct, ovarian cancer research. Taira y, hirakawa m, nagayama c, ikemiyagi k, touma t, tokashiki m. Stage 2 granulosa cell as the cells had surfaced on the tumor which was also stuck to my bladder and now i find myself wondering if it will return there. Adult granulosa cell tumors of the ovary are rare neoplasms, accounting for less than 5% of all ovarian malignancies. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for granulosa cell tumor of the. Genomic profiling of primary and recurrent adult granulosa. Typically, only one ovary is affected with a granulosa cell tumor, and the other ovary will be found to be smaller in size and inactive due to hormones that are being produced by the affected ovary.
Granulosa cell tumor gct is the most common sex cordstromal tumor that stem from granulosa cells. Granulosa cell tumors of the equine ovary american. While granulosacell tumors are the most common type of ovarian tumor, producing precocious puberty, they only account for about 10% of. Gcts vary in size from relatively small, solid, yellow to white structures to large structures composed of multiple cysts, a single large cystic structure, or a. Granulosa cell tumor can be diagnosed by using radiological imaging tools. Apr 30, 2010 granulosa cell tumor is a slowgrowing cancer that starts in the granulosa cells that surround the eggs within the ovary. Ovarian granulosa cell tumors gcts are divided into adult gct agct and juvenile gct jgct. Immunohistochemistry of ovarian granulosa cell tumours. The embryological origin of granulosa cells remains controversial. Successful treatment of adulttype granulosa cell tumor of the ovary by palliative radiotherapy. A retrospective analysis of ten cases of adult granulosa cell tumor of. Request pdf granulosa cell tumors of the ovary ovarian granulosa cell tumors tgo are rare neoplasms. The patient was found to have a stage ic granulosa cell tumor of the ovary despite undergoing annual gynecologic examinations. Granulosa cell tumors of the ovary gct represent a specific subset of malignant ovarian tumors and can be further categorized into two distinct subtypes, the juvenile and the adult form.
Granulosa cell tumor of the ovary genetic and rare diseases. Granulosa cell tumors of the ovary with precocious puberty. In addition, gct is a vascular tumor that may occasionally. Nov 15, 2005 a composite mucinous and granulosa cell tumor of the ovary in a 76. The molecular mechanism of ovarian granulosa cell tumors. A 54 years old female patient presented with a mass and acute pain in abdomen. Clinical and pathologic prognostic factors in adult granulosa. Although granulosa cells normally occur only in the ovary, granulosa cell tumours occur in both ovaries and testicles see ovarian cancer and.
Adult granulosa cell tumor agct is a sex cord stromal tumor scst which constitutes 25% of all ovarian. Small, bland, cuboidal to polygonal cells in various patterns, including callexner bodies small folliclelike structures filled with acidophilic material, macrofollicular, trabecular, solid and insular patterns. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Rapidly growing juvenile granulosa cell tumor of the ovary arising in. Although jgct have different histologic features compared to agct, the two types have similar imaging features because they have similar. Also baumann described ovarian granulosa cell tumor in bovine weighing 17. Granulosa cell tumor of the ovary requires regular, longterm. At laparotomy this tumor proved to be a solid and cystic mass measuring 10 cm in greatest diameter. Objective adult granulosa cell tumors agcts account for less than 5 % of all ovarian malignancies, whereas the majority 95 % occurs after the age of 30 adulttype and present at an early stage.
Granulosa tumors tgo are a rare entity of malignant ovarian tumors 5%. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors mgct. Paraffinembedded material of 47 ovarian tumours primarily diagnosed as granulosa cell tumours, including 2 cases of juvenile granulosa cell tumour, were studied immunohistochemically for the presence of intermediate filament proteins, epithelial membrane antigen and tumour markers. Functional neoplasms of the ovary are relatively infrequent compared to ovarian tumors in general, and only about 5% occur before puberty. The common types are granulosa cell tumors, fibrothecomas, sclerosing stromal tumors, and sertolileydig cell tumors. These tumors can also affect the reproductive capability of a mare intended for breeding due to elevations in reproductive hormones. Extraovarian granulosa cell tumor gct is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. Granulosa cell tumor of the ovary may create a diagnostic challenge in cytologic preparations. Within recent years granulosa theca cell tumors have attracted much interest, primarily because of their hormonal function. This tumor is classified into juvenile gct and adult gct, and the majority of the cases are the adult type. Recurrences usually occur in median at 5 years after the. Adulttype granulosa cell tumor agct is a rare malignant ovarian sex cordstromal tumor, harboring recurrent foxl2 c. Radiation oncologyovarygranulosa cell tumor wikibooks. Granulosa cell tumor ovary treatment, diagnosis, symptoms.
They are hormonesecreting and give rise to granulomatous and thecal cells of the ovary, thus forming part of the group of tumors of the sex cords and the stroma of the ovary. Molecular pathogenesis of granulosa cell tumors of the ovary. However, gct of the ovary requires regular and longterm followup with a doctor, including an annual blood test to check for markers that could indicate the cancers. They arise from sex cord stromal cells of the ovaries. The new molecular biology of granulosa cell tumors of the ovary. Granulosa cell tumors gcts of the ovary are relatively uncommon neoplasms, representing approximately 5 to 10% of all ovarian malignancies 1, 2. Granulosa cell tumor of the ovary genetic and rare. Value of inhibin in the identification of granulosa cell tumors of the. The agct is more common type, conversely, less than 5% of tumors are the jgct and occur in mainly premenarchal girls and in women younger than 30 years. If you are facebook, there is a page for the granulosa cell tumor foundation in new zeland. Pathological examination returned to a left ovarian tumoral process evoking a tumor of the sex cords. Granulosa cell tumors gct of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases.
This report presents a case of granulosa cell tumor of the ovary after the long. They are estrogen secreting tumors and present as large, complex, ovarian masses. Gct accounts for 2% to 5% of all ovarian cancers and can be divided into two subtypes according to the differences of the age of patients, clinical and histopathologic features. Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors.
Granulosa cell tumor gct is a rare ovarian tumor originating from sex cord stromal cells 1. Md anderson, 1999 19491988 pmid 10094877 radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. Pdf molecularly defined adult granulosa cell tumor of. Granulosa cell tumor of the ovary journal of clinical. Granulosa cell tumors of the ovary account for less than 5% of all malignant ovarian tumors but represent the most common malignant sex cordstromal tumor and the most common clinically estrogenic ovarian tumor. Dec 14, 2018 ovarian granulosa cell tumors gcts are divided into adult gct agct and juvenile gct jgct.
The new molecular biology of granulosa cell tumors of the. May 21, 2012 the patient was found to have a stage ic granulosa cell tumor of the ovary despite undergoing annual gynecologic examinations. The immunohistochemical study diagnosed an adult granulosa tumor. A retrospective analysis of 26 patients of granulosa cell tumor of ovary from 2002 to 2011 was carried out. Recently i have be diagnosed with granulosa cell tumor of the ovary. I would like to hear and talk to other people who have this same type of cancer. In the 1970s, evidence emerged that the first cells to make contact with the oogonia were of mesonephric origin. It is an uncommon primary malignant tumor of the ovary and represents 2% to 5% of all ovarian cancers. Cytology of granulosa cell tumor of the ovary american. Pdf granulosa cell tumors are rare neoplasms characterized by long natural. Cisplatincontaining regimen in advanced or recurrent. Review article pathogenesis and treatment of adulttype granulosa cell tumor of the ovary anniina farkkil aa,b, ullamaija haltiaa,b, johanna tappera, melissa k. Granulosa cell tumour an overview sciencedirect topics.
These tumours are part of the sex cordgonadal stromal tumour or nonepithelial group of tumours. Athanassiou 1st department of medical oncology, metaxas cancer hospital, piraeus, greece. The records of all patients were analyzed to determine clinical presentation, treatment, survival, and prognostic factors. The aim of this study was to explore the clinicopathological characteristics of recurrent adulttype granulosa cell tumor of the ovary agcot and evaluated the treatment results to define the prognostic parameters for survival after recurrence. Adult granulosa cell tumors agcts are the most common sex cordstromal tumors. The adult form is the most common tracing a very typical clinical pathological profile with a slow progression and recurrence that occurs long. Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage. From the department of obstetrics and gynecology, university of wisconsin n the 45 cases of malignancy of the ovary proved by microscopic examination at the wisconsin general hospital during the past eight years, five have been granulosa cell tumors. Adult granulosa cell tumor of left ovary of 92 year old mexican american woman. In 30 consecutive patients with a stage iiii granulosa cell tumor, inhibin a and b concentrations were measured in pre and posttreatment serum samples. Sep 11, 2012 granulosa cell tumors gcts of the ovary account for 2 to 5 of ovarian malignancies. Granulosa cell tumors of the ovary comprise a distinct subset of ovarian cancers that account for approximately 5% of all ovarian malignancies 6. Gct exhibit a molecular profile that is consistent with fshresponsive granulosa cells of the late preovulatoy follicle 1, 2. Pdf download for granulosa cell tumor of the ovary.
This type of tumor is known as a sex cordstromal tumor and usually occurs in adults. Within recent years granulosathecacell tumors have attracted much interest, primarily because of their hormonal function. Diagnosed and treated early, its not likely to return. More detailed information about the symptoms, causes, and treatments of granulosa cell tumor of the ovary is available below.
The foxl2 c4w mutation is characteristic of adult granulosa. Gcts of the ovary belong to the group of ovarian sexcord stromal tumors. I have been told that a total hysterectomy should follow. Our experience with needle aspiration material, ascitic fluid, and peritoneal washings indicates that in fluids, despite some similarity between the tumor cells and reactive mesothelial cells, a correct diagnosis can be achieved by careful examination. It was suggested that mesonephric cells already closely associated with the oogonia proliferated throughout development to form the granulosa cell layer. Granulosa cell tumor of the ovary symptoms, diagnosis. We present two patients with malignant ovarian adult gct. Granulosa cell tumors of the ovary are a type of sex cord stromal ovarian tumor. Ct and mri findings of sex cordstromal tumor of the ovary.
The patient had left adnexectomy, peritoneal cytology. A rare type of ovarian tumor which can cause excess estrogen hormone production. Cytomorphology and clinicopathologic correlation of the. Granulosa cell tumor is restricted at the ovary without having intracystic papillary protrusions. However, high umbilical cord serum concentrations brenner tumors, lipoid cell tumors of the ovary, sclerosing stromalcell tumors, and adrenal tumors. In the other, an aromatase inhibitor was effective for recurrent malignant gct. Rapidly growing juvenile granulosa cell tumor of the ovary. Aug 25, 2009 granulosa cell tumors gcts of the ovary are relatively uncommon neoplasms, representing approximately 5 to 10% of all ovarian malignancies 1, 2. Clinical and pathologic prognostic factors in adult. Although jgct have different histologic features compared to agct, the two types have similar imaging features because they have similar gross. Adult granulosa cell tumor gct of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen.